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Tuberculosis
Findings in tuberculosis reported from University of Milan
April 21st, 2009
According to a study from Milan, Italy, "Mycobacterium tuberculosis glutamyl-tRNA synthetase (Mt-GluRS), encoded by Rv2992c, was overproduced in Escherichia coli cells, and purified to homogeneity. It was found to be similar to the other well-characterized GluRS, especially the E. coli enzyme, with respect to the requirement for bound tRNA(Glu) to produce the glutamyl-AMP intermediate, and the steady-state kinetic parameters k(cat) (130 min(-1)) and K-M for tRNA (0.7 mu m) and ATP (78 mu m), but to differ by a one order of magnitude higher K-M value for l-Glu (2.7 mm)." "At variance with the E. coli enzyme, among the several compounds tested as inhibitors, only...
Source: TB & Outbreaks Week (2009-04-21)
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