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Leishmaniasis
Reports outline leishmaniasis research from Johann Wolfgang Goethe University
April 28th, 2009
"Resistance to leishmaniasis in C57BL/6 mice depends on Th1/Te1 cells. BALB/c mice preferentially develop Th2 immunity and succumb to infection," scientists in Mainz, Germany report. "We now assessed the role of IL-17 in cutaneous leishmaniasis. During the course of Leishmania major infection, BALB/c CD4 cells and neutrophils produced increased amounts or IL-17 as compared with cells from C57BL/6 mice. This increase was associated with significantly increased IL-23 release from L. major-infected BALB/c dendritic cells (DC), whereas IL-6 and TGF-beta 1 production by BALB/c and C57BL/6 DC were comparable. Interestingly, lesion sizes in infected IL-17-deficient BALB/c mice...
Source: TB & Outbreaks Week (2009-04-28)
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