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Life Sciences
Research results from A. Bijev and co-authors update knowledge of life sciences
April 28th, 2009
According to a study from Sofia, Bulgaria, "Fourteen new hydrazones representing derivatives of pyrrole were synthesized by condensation of six carbohydrazides with ten carbonyl compounds. The new products were evaluated as potential tuberculostatics by means of two levels of high-throughput screening." "The preliminary screening against Mycobacterium tuberculosis H37Rv (ATCC 27294) at 6.25 mu g/mL in 12B medium using the Microplate Alamar Blue Assay measured the inhibitory activity within the total series in the range of 98-0%. Compound 34 (N'4-[1-(4-acetyl-3,5-dimethyl-1H-2-pyrrolyl)-methylidene]-4-pyridinecarbohydrazide) was identified as the compound showing the...
Source: TB & Outbreaks Week (2009-04-28)
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