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Mycobacteria
New mycobacteria study findings reported from Charles University
April 28th, 2009
"A gseries of 29 new derivatives of N-benzylsalicylthioamides was synthesized and the compounds were tested for in-vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium," scientists writing in the journal Archiv der Pharmazie report. "The activity was analyzed by quantitative structure-activity relationship (QSAR). Activity increased with increasing lipophilicity and electron donating effect of the substituents in the acyl moiety and decreased with the electrophilic superdelocalizability of the molecules," wrote R. Dolezal and colleagues, Charles University. The researchers...
Source: TB & Outbreaks Week (2009-04-28)
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