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Tuberculosis
New findings from M. Vidyarani and co-researchers in the area of tuberculosis described
April 28th, 2009
"Vitamin D receptor (VDR) genotypes have been shown to be associated with differential susceptibility or resistance to tuberculosis. The influence of Fokl, Bsml, Apal and Taql variants of VDR gene on 1, 25(OH)(2) D-3 modulated granzyme A expression of cytotoxic lymphocytes induced by culture filtrate antigen (CFA) of Mycobacterium tuberculosis was studied in 40 pulmonary tuberculosis (PTB) patients and 49 normal healthy subjects (NHS) by flow cytometry," scientists in Madras, India report. "In both the study groups, addition of 1, 25(OH)(2) D-3 (10(-7)M) significantly reduced the percentage of granzyme A positive cells in both unstimulated (NHS, p<0.0001; PTB,...
Source: TB & Outbreaks Week (2009-04-28)
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