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Enzyme Research
Vrije University Amsterdam details research in enzyme research
April 28th, 2009
"The diarylquinoline TMC207 kills Mycobacterium tuberculosis by specifically inhibiting ATP synthase. We show here that human mitochondrial ATP synthase (50% inhibitory concentration [IC50] of >200 mc M) displayed more than 20,000-fold lower sensitivity for TMC207 compared to that of mycobacterial ATP synthase (IC50 of 10 nM)," scientists in Netherlands report. "Also, oxygen consumption in mouse liver and bovine heart mitochondria showed very low sensitivity for TMC207. These results suggest that TMC207 may not elicit ATP synthesis-related toxicity in mammalian cells," wrote A.C. Haagsma and colleagues, Vrije University Amsterdam. The researchers...
Source: TB & Outbreaks Week (2009-04-28)
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