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BioMed Central
Rifampin kinetics poor in children
May 5th, 2009
Rifampin (RMP), a first-line antituberculosis drug, reaches serum concentrations well below suggested lower limits when a standard dose of 8-12mg/kg body weight is given to children. A pharmacokinetic study, published in the open access journal BMC Medicine, suggests that a higher dose of 10-20mg/kg may be more appropriate. H. Simon Schaaf from the University of Stellenbosch, South Africa, led a team of researchers who studied 54 children admitted to hospital with severe tuberculosis, 21 of whom also had HIV infection. He said, "The mean calculated 2h RMP concentrations in these HIV-infected and HIV-uninfected children were 3.9 and 4.8μg/ml, respectively, at...
Source: TB & Outbreaks Week (2009-05-05)
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