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Tuberculosis
New data from University of Oxford illuminate research in tuberculosis
May 5th, 2009
"In Myobacterium tuberculosis, the genes hsaD (2-hydroxy-6oxo-6-phenylhexa-2,4-dienoic acid hydrolase) and nat (arylamine N-acetyltransferase) are essential for survival inside of host macrophages. These genes act Lis an operon and have been Suggested to he involved in cholesterol metabolism," researchers in Oxford, the United Kingdom report. "However, the role of NAT in this catabolic pathway has not been determined. In in effort to better understand the function of these proteins, we have expressed, purified and characterized TBNAT (NAT from M. tuberculosis) and HsaD (2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase) from M. tuberculosis. Both proteins...
Source: TB & Outbreaks Week (2009-05-05)
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