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Tuberculosis
Research conducted at Texas A&M University has provided new information about tuberculosis
May 5th, 2009
"Triclosan has been previously shown to inhibit InhA, on essential enoyl acyl carrier protein reductase involved in mycolic acid biosynthesis, the inhibition; of which leads to the of Mycobacterium tuberculosis. Using, a structure-based drug design approach, a series of 5-substituted triclosan derivatives was developed," researchers in the United States report. "Two groups of derivatives with alkyl and aryl substituents, respectively, were identified with dramatically enhanced potency against purified InhA. The most efficacious inhibitor displayed an IC50 value of 21 nM, which was 50-fold more Potent than tricloson. X-ray crystal structures of InhA in complex with four...
Source: TB & Outbreaks Week (2009-05-05)
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