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Tuberculosis
Researchers at City University of New York publish new data on tuberculosis
May 5th, 2009
"Catalase-peroxidase (KatG) is essential in Mycobacterium tuberculosis for oxidative stress management and activation of the antitubercular pro-drug isoniazid. The role of a unique distal side adduct found in KatG enzymes, involving linked side chains of residues Met(255), Tyr(229), and Trp(107) (MYW), in the unusual catalase activity of KatG is addressed here and in our companion paper (Suarez, J., Ranguelova, K., Jarzecki, A. A., Manzerova, J., Krymov, V., Zhao, X., Yu, S., Metlitsky, L., Gerfen, G. J., and Magliozzo, R. S. (2009) J. Biol. Chem. 284, in press)," investigators in the United States report. "The KatG[W107F] mutant exhibited severely reduced catalase...
Source: TB & Outbreaks Week (2009-05-05)
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