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Tuberculosis
Researchers from College of Medicine publish new studies and findings in the area of tuberculosis
May 5th, 2009
According to a study from the United States, "The enzyme alpha-isopropylmalate synthase from Mycobacterium tuberculosis (MtIPMS) has been identified as a possible target for the design of new antitubercular therapeutics. Recently, it was shown that MtIPMS is subject to slow-onset, feedback inhibition by L-leucine, the first instance of an allosteric regulator utilizing this mechanism." "Structural studies are inconsistent with canonical allosteric mechanisms, including changes to the quaternary structure or large, rigid-body conformational changes to the enzyme upon L-leucine binding. Thus, the allosteric regulation may result from a discrete inhibitory signal...
Source: TB & Outbreaks Week (2009-05-05)
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