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Escherichia Coli
Scientists at University of Wisconsin describe research in Escherichia coli
May 12th, 2009
According to recent research from the United States, "Escherichia coli O157:H7 is a human enteric pathogen that causes hemorrhagic colitis which can progress to hemolytic uremic syndrome, a severe kidney disease with immune involvement. During infection, E. coli O157:H7 secretes StcE, a metalloprotease that promotes the formation of attaching and effacing lesions and inhibits the complement cascade via cleavage of mucin-type glycoproteins. We found that StcE cleaved the mucin-like, immune cell-restricted glycoproteins CD43 and CD45 on the neutrophil surface and altered neutrophil function." "Treatment of human neutrophils with StcE led to increased respiratory burst...
Source: TB & Outbreaks Week (2009-05-12)
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