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TB & Outbreaks Week

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Gene Therapy



Reports outline gene therapy study results from Yale University



May 12th, 2009

According to recent research published in the journal Plos Pathogens, "Legionella pneumophila is an opportunistic pathogen that can cause a severe pneumonia called Legionnaires' disease. In the environment, L. pneumophila is found in fresh water reservoirs in a large spectrum of environmental conditions, where the bacteria are able to replicate within a variety of protozoan hosts."

"To survive within eukaryotic cells, L. pneumophila require a type IV secretion system, designated Dot/Icm, that delivers bacterial effector proteins into the host cell cytoplasm. In recent years, a number of Dot/Icm substrate proteins have been identified; however, the function of...


Source: TB & Outbreaks Week (2009-05-12)

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