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Life Sciences
Researchers from George Washington University detail new studies and findings in the area of life sciences
May 12th, 2009
According to recent research published in the Journal of Medicinal Chemistry, "The 4-nitroimidazole PA-824 is active against aerobic and anaerobic Mycobacterium tuberculosis (Mtb) while 5-nitroimidazoles like metronidazole are active against only anaerobic Mtb. We have synthesized analogues of both 4- and 5-nitroimidazoles and explored their antitubercular activities." "The nitro group is required for both activities in all compounds. The key determinants of aerobic activity in the 4-nitroimidazoles include the bicyclic oxazine, the lipophilic tail, and the 2-position oxygen. For the 5-nitroimidazoles. neither the corresponding bicyclic analogue not-addition of a...
Source: TB & Outbreaks Week (2009-05-12)
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