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Bird Flu
Studies from P.W. Yuan and colleagues reveal new findings on bird flu
May 12th, 2009
"The heterotrimeric influenza virus polymerase, containing the PA, PB1 and PB2 proteins, catalyses viral RNA replication and transcription in the nucleus of infected cells. PB1 holds the polymerase active site(1) and reportedly harbours endonuclease activity(2), whereas PB2 is responsible for cap binding(2-4)," researchers in Beijing, People's Republic of China report. "The PA amino terminus is understood to be the major functional part of the PA protein and has been implicated in several roles, including endonuclease(5) and protease activities(6) as well as viral RNA/complementary RNA promoter binding(7). Here we report the 2.2 angstrom (angstrom) crystal structure of...
Source: TB & Outbreaks Week (2009-05-12)
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