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Tuberculosis
Investigators at University of Michigan, Medical Department zero in on tuberculosis
May 12th, 2009
"Mycobacterium tuberculosis is one of the world's most deadly human pathogens; an integrated understanding of how it successfully survives in its host is crucial to developing new treatment strategies. One notable characteristic of infection with M. tuberculosis is the formation of granulomas, aggregates of immune cells whose structure and function may reflect success or failure of the host to contain infection," scientists in the United States report. "One central regulator of host responses to infection, including granuloma formation, is the pleiotropic cytokine TNF-alpha. Experimental work has characterized roles for TNF in macrophage activation; regulation of...
Source: TB & Outbreaks Week (2009-05-12)
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