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TB & Outbreaks Week

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Cytokines



Researchers from University of Montreal describe findings in cytokines



May 19th, 2009

According to recent research from Canada, "Streptococcus suis is a major pathogen of swine, causing mainly meningitis, and it also represents an emerging zoonotic agent. We investigated its ability to induce the release of pro-inflammatory cytokines and chemokines by porcine brain microvascular endothelial cells (PBMEC)."

"We demonstrated that live S. suis induced a strong release of interleukin (IL)-6 and IL-8 by PBMEC. We showed that the suilysin (hemolysin) was largely responsible for such stimulation, although cell wall components also contribute to cell stimulation but to a considerably lower extent. Interestingly, IL-8 production by PBMEC became undetectable by...


Source: TB & Outbreaks Week (2009-05-19)

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