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TB & Outbreaks Week

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Hemorrhagic Fever



New hemorrhagic fever data have been reported by M. Simon and co-authors



May 19th, 2009

"Following binding and entry many viruses exploit the host cell cytoskeleton to ensure intracellular transport, assembly or egress. For Crimean-Congo hemorrhagic fever virus (CCHFV), the causative agent of a severe hemorrhagic disease, virus-host interactions are poorly investigated," scientists in Stockholm, Sweden report.

"In this study we demonstrated that drug-induced suppression of microtubule dynamics and especially microtubule disassembly, impaired CCHFV biogenesis. Our results showed that intact microtubules were required early during virus internalization, and late, during virus assembly and egress. Furthermore, disruption of microtubules resulted in reduced...


Source: TB & Outbreaks Week (2009-05-19)

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