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Influenza
Data on influenza described by researchers at National Institutes of Health
May 19th, 2009
"The 1918 influenza pandemic caused more than 40 million deaths and likely resulted from the introduction and adaptation of a novel avian-like virus. Influenza A virus hemagglutinins are important in host switching and virulence," researchers in the United States report. "Avian-adapted influenza virus hemagglutinins bind sialic acid receptors linked via alpha 2-3 glycosidic bonds, while human-adapted hemagglutinins bind alpha 2-6 receptors. Sequence analysis of 1918 isolates showed hemagglutinin genes with alpha 2-6 or mixed alpha 2-6/alpha 2-3 binding. To characterize the role of the sialic acid binding specificity of the 1918 hemagglutinin, we evaluated in mice...
Source: TB & Outbreaks Week (2009-05-19)
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