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Life Sciences
Research from X. Serranomartin et al broadens understanding of life sciences
May 19th, 2009
According to recent research published in the journal Antimicrobial Agents and Chemotherapy, "Leishmaniasis represents a serious public health problem worldwide. The first line of treatment is based on glucantime and pentostan, which generate toxic effects in treated patients." "We have recently shown that amiodarone, frequently used as an antiarrhythmic, possesses activity against Trypanosoma cruzi through the disruption of mitochondrial Ca2+ homeostasis and the inhibition of parasite ergosterol biosynthesis, specifically at the level of oxidosqualene cyclase activity (G. Benaim, J. Sanders, Y. Garcia-Marchan, C. Colina, R. Lira, A. Caldera, G. Payares, C....
Source: TB & Outbreaks Week (2009-05-19)
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