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Bird Flu
Data on bird flu published by S. Yongkiettrakul and colleagues
May 19th, 2009
According to recent research from Pathum Thani, Thailand, "The study reports heterologous expression in Pichia pastoris of active neuraminidase derived from avian influenza virus A/Viet Nam/DT-036/2005(H5N1). A gene encoding the neuraminidase N1 head domain (residues 63-449) was fused directly in-frame with the Saccharomyces cerevisiae alpha-factor secretion signal in pPICZ(A vector." "Recombinant N1 neuraminidase was expressed in P pastoris as a 72 kDa secreted, soluble protein. Glycopeptidase F treatment generated a 45 kDa product, indicating that the secreted recombinant N1 neuraminidase is an N-linked glycoprotein. Kinetic studies and inhibition tests with...
Source: TB & Outbreaks Week (2009-05-19)
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