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Drug Development
Research on drug development detailed by P. Palit and co-authors
May 26th, 2009
According to recent research from Calcutta, India, "A one-pot synthesis of some novel bis-quinolines has been achieved under phase transfer catalyzed conditions using 8-hydroxy quinoline derivatives as substrates. The synthesized analogues were evaluated for antileishmanial activity against Leishmania donovani promastigotes and amastigotes." "The entire bis-quinolines showed efficacy in both in vitro and in vivo studies. Compound 5 (1,1-bis-[(5-chloro-8-quinolyl)oxy] methane) exhibited the most significant activity. Compounds 4 (1,1-bis-[(8-quinolyl)oxylmethane) and 9 (1,5-bis-[(2-methyl-8-quinolyl)oxy] pentane) also demonstrated significant leishmanicidal efficacy...
Source: TB & Outbreaks Week (2009-05-26)
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