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Tuberculosis
Researchers from National Institute of Standards and Technology describe findings in tuberculosis
May 26th, 2009
According to recent research published in the Journal of Biological Chemistry, "The cyclic AMP receptor protein (CRP, also called catabolite gene activator protein or CAP) plays a key role in metabolic regulation in bacteria and has become a widely studied model allosteric transcription factor. On binding its effector cAMP in the N-terminal domain, CRP undergoes a structural transition to a conformation capable of specific DNA binding in the C-terminal domain and transcription initiation." "The crystal structures of Escherichia coli CRP (EcCRP) in the cAMP-bound state, both with and without DNA, are known, although its structure in the off state (cAMP-free,...
Source: TB & Outbreaks Week (2009-05-26)
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