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Drug Resistance
Reports from Medical School advance knowledge in drug resistance
May 26th, 2009
Data detailed in 'Enhanced heterogeneity of rpoB in Mycobacterium tuberculosis found at low pH' have been presented. "The aim of this study was to gain an insight into the molecular mechanisms of the evolution of rifampicin resistance in response to controlled changes in the environment. We determined the proportion of rpoB mutants in the chemostat culture and characterized the sequence of mutations found in the rifampicin resistance-determining region of rpoB in a steady-state chemostat at pH 7.0 and 6.2," investigators in London, the United Kingdom report. "The overall proportion of rpoB mutants of strain H37Rv remained constant for 37 days at pH 7.0, ranging between...
Source: TB & Outbreaks Week (2009-05-26)
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