TB & Outbreaks Week
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of TB & Outbreaks Week
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Leishmaniasis
Research conducted at S. Kar and co-authors has provided new information about leishmaniasis
June 2nd, 2009
According to a study from Calcutta, India, "Curative effect of cystatin, a natural cystein protease inhibitor, on experimental visceral leishmaniasis was associated with strong upregulation of iNOS. The transductional mechanisms underlying this cellular response was investigated in the murine macrophage cell line RAW 264.7 and in the BALB/c mouse model of visceral leishmaniasis." "Cystatin synergizes with IFN-gamma in inducing ERK1/2 phosphorylation and NF-kappa B DNA-binding activity. Pretreatment of cells with specific inhibitors of NF-kappa B or ERK1/2 pathway blocked the cystatin plus IFN-gamma-inducible NF-kappa B activity and markedly reduced the expression of...
Source: TB & Outbreaks Week (2009-06-02)
|
