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Life Sciences
Research from Federal University in the area of life sciences published
June 2nd, 2009
According to a study from Niteroi, Brazil, "Newly synthesized pyrazole carbohydrazide derivatives with substituents X = Br/Y = NO, and X = NO2/Y = Cl were independently investigated in the CBA mouse model of cutaneous leishmaniasis. Animals were infected with Leishmania amazonensis and treated two weeks after the parasitic infection with the pyrazole carbohydrazides for 45 days." "Oral treatment with both compounds controlled evolution of footpad cutaneous lesions and dissemination of parasites to draining lymph nodes. Nitric oxide generation was observed in supernatants of lymph node cells from infected CBA mice that were treated with these compounds. The pyrazole...
Source: TB & Outbreaks Week (2009-06-02)
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