TB & Outbreaks Week
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Tuberculosis
Reports outline tuberculosis research from University of Manchester
June 2nd, 2009
"The secreted Mycobacterium tuberculosis protein tyrosine phosphatase (MptpB) is a virulence factor for M. tuberculosis and contributes to its survival within host macrophages. The aim of this study was to identify potent selective inhibitors of MptpB and to determine the efficacy of these compounds in mycobacterium-infected macrophages," scientists in Manchester, the United Kingdom report. "The inhibitory effect of a small library of compounds on MptpB was first examined in vitro. The efficacy of these compounds was further examined in mycobacterium-infected macrophages. We have identified a new family of double-site isoxazole-based compounds that are potent selective...
Source: TB & Outbreaks Week (2009-06-02)
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