TB & Outbreaks Week
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Vaccines
Reports from C. Herreranajera et al highlight recent research in vaccines
June 2nd, 2009
"Leishmaniasis is a neglected disease with an estimated 12 million infected people. The recent completion of the sequencing of the Leishmania major genome has opened opportunities for the identification of targets for vaccine development," scientists writing in the journal Proteomics report. "We present here the first attempt at identifying novel vaccine candidates by whole genome analysis. We predicted CD8(+) T cell epitopes from the L. major proteome and validated in vivo in mice the immunogenicity of some of the best predicted epitopes. Consensus epitope predictions from 8272 annotated protein sequences with 5-8 different algorithms allowed the identification...
Source: TB & Outbreaks Week (2009-06-02)
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