TB & Outbreaks Week
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Escherichia Coli
Study data from Queen's University provide new insights into Escherichia coli
June 9th, 2009
According to a study from Kingston, Canada, "For many pathogenic microorganisms, iron acquisition from host heme sources stimulates growth, multiplication, ultimately enabling successful survival and colonization. In gram-negative Escherichia coli O157:H7, Shigella dysenteriae and Yersinia enterocolitica the genes encoded within the heme utilization operon enable the effective uptake and utilization of heme as an iron source." "While the complement of proteins responsible for heme internalization has been determined in these organisms, the fate of heme once it has reached the cytoplasm has only recently begun to be resolved. Here we report the first crystal structure of...
Source: TB & Outbreaks Week (2009-06-09)
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