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Influenza
Data from N. Sriwilaijaroen et al provide new insights into influenza
June 9th, 2009
"The initial step essential in influenza virus infection is specific binding of viral hemagglutinin to host cell-surface glycan receptors. Influenza A virus specificity for the host is mediated by viral envelope hemagglutinin, that binds to receptors containing glycans with terminal sialic acids," investigators in Japan report. "Human viruses preferentially bind to alpha 2 -> 6 linked sialic acids on receptors of host cells, whereas avian viruses are specific for the alpha 2 -> 3 linkage on the target cells. Human influenza virus isolates more efficiently infect amniotic membrane (AM) cells than chorioallantoic membrane (CAM) cells. N-glycans were isolated from AM...
Source: TB & Outbreaks Week (2009-06-09)
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