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Life Sciences
Studies from G. Etienne et al add new findings in the area of life sciences
June 9th, 2009
"Lipooligosaccharides (LOS) are highly antigenic glycolipids produced by a number of Mycobacterium species, which include ''M. canettii,'' a member of the M. tuberculosis complex, and the opportunistic pathogens M. marinum and M. kansasii. The various LOS share a core composed of trehalose esterified by at least 1 mole of polymethyl-branched fatty acid (PMB-FA) and differ from one another by their oligosaccharide extensions," scientists in Toulouse, France report. "In this study, we identified a cluster of genes, MSMEG_4727 through MSMEG_4741, likely involved in the synthesis of LOS in M. smegmatis. Disruption of MSMEG_4727 (the ortholog of pks5 of M. tuberculosis),...
Source: TB & Outbreaks Week (2009-06-09)
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