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Tuberculosis
Findings from J.K. Capyk et al in tuberculosis reported
June 9th, 2009
"KshAB (3-Ketosteroid 9 alpha-hydroxylase) is a two-component Rieske oxygenase (RO) in the cholesterol catabolic pathway of Mycobacterium tuberculosis. Although the enzyme has been implicated in pathogenesis, it has largely been characterized by bioinformatics and molecular genetics," scientists in Vancouver, Canada report. "Purified KshB, the reductase component, was a monomeric protein containing a plant-type [2Fe-2S] cluster and FAD. KshA, the oxygenase, was a homotrimer containing a Rieske [2Fe-2S] cluster and mononuclear ferrous iron. Of two potential substrates, reconstituted KshAB had twice the specificity for 1,4-androstadiene-3,17-dione as for...
Source: TB & Outbreaks Week (2009-06-09)
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