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Tuberculosis
New tuberculosis research from University of Delhi discussed
June 9th, 2009
According to a study from Delhi, India, "The induction of apoptosis of T cells by intracellular pathogen is an attractive hypothesis to explain their persistence in host cells. To test this hypothesis, human monocyte-derived macrophages were infected with Mycobacterium tuberculosis H37Rv and cocultured with autologous T cells stimulated with nonspecific phytohemagglutinin (PHA) or specific culture filtrate protein (CFP) of M. tuberculosis." "CD95 (Fas) expression, propidium iodide (PI) staining and terminal deoxy nucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay of CD3 cells were studied to assess the viability. Apoptotic cells were correlated...
Source: TB & Outbreaks Week (2009-06-09)
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