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Dengue Fever
Researchers from Nanyang Technological University report details of new studies and findings in the area of dengue fever
June 9th, 2009
"The flavivirus envelope glycoprotein (E) is responsible for viral attachment and entry by membrane fusion. Its ectodomain is the primary target of the humoral immune response," scientists writing in the Journal of General Virology report. "In particular, the C-terminal Ig-like domain III of E, which is exposed at the surface of the viral particle, forms an attractive antigen for raising protective monoclonal antibodies (mAb). 9F12, a mouse mAb raised against a dengue virus (DENV) serotype 2 recombinant domain 111, cross-reacts with corresponding domains from the other three DENV serotypes and also with West Nile virus. mAb 9F12 binds with nanomolar affinity to a...
Source: TB & Outbreaks Week (2009-06-09)
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