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DNA Vaccines
Scientists at Wuhan University, Medical Department describe research in DNA vaccines
June 9th, 2009
According to recent research from Wuhan, People's Republic of China, "Plasmid DNA vaccines have been widely explored for use in tuberculosis immunization but their immunogenicity needs improvement. In the present study, we incorporated the bovine herpesvirus 1 VP22 (BVP22)-encoding gene, which encodes a protein that demonstrates a capability for disseminating the expressed antigen to neighbouring cells, into a DNA vector in which it was fused to the Ag85B-encoding gene of Mycobacterium tuberculosis (Mtb), and investigated whether this linkage could enhance immune response and protective efficacy in C57BL/6 mice compared to plasmid DNA encoding Ag85B alone." "After...
Source: TB & Outbreaks Week (2009-06-09)
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