TB & Outbreaks Week
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Life Sciences
Reports from Indiana University add new data to research in life sciences
June 16th, 2009
"Bacillus subtilis CsoR (Bsu CsoR) is a copper-sensing transcriptional repressor that regulates the expression of the copZA operon encoding a copper chaperone and a Cu efflux P-type ATPase, respectively. Bsu CsoR is a homologue of Mycobacterium tuberculosis CsoR (Mtb CsoR), representative of a large Cu(I)-sensing regulatory protein family," investigators in the United States report. "We show here that Bsu CsoR binds approximate to 1 mol equiv of Cu(I) per monomer in vitro with an affinity >= 10(21) M-1. X-ray absorption spectroscopy shows Cu(I) adopts a trigonal S2N coordination like Mtb CsoR. Both apo and Cu(I)-bound Bsu CsoR are stable tetramers in the low...
Source: TB & Outbreaks Week (2009-06-16)
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