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Tick-Borne Encephalitis
New tick-borne encephalitis study findings have been published by K. Ellencrona and colleagues
June 16th, 2009
According to recent research from Huddinge, Sweden, "Dengue virus (DENV) and tick-borne encephalitis virus (TBEV) are flaviviruses, which can cause lethal hemorrhagic fever and encephalitis, respectively. Here, we demonstrate that the TBEV-NS5 and DENV-NS5 proteins use an internal binding mechanism to target human PDZ proteins." "TBEV-NS5 has high affinity to regulating synaptic membrane exocytosis-2 (RIMS2) and Scribble, whereas DENV-NS5 binds primarily to the tight junction protein zonula occludens-1 (ZO-1). Targeting of TBEV-NS5 to the plasma membrane is stabilised by ZO-1; however, DENV-NS5 co-localises with ZO-1 in the nucleus," wrote K. Ellencrona and...
Source: TB & Outbreaks Week (2009-06-16)
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