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Legionnaire Disease
New legionnaire disease research from T. Sahr and co-researchers described
June 23rd, 2009
"To transit from intra- to extracellular environments, Legionella pneumophila differentiates from a replicative/non-virulent to a transmissive/ virulent form using the two-component system LetA/LetS and the global repressor protein CsrA. While investigating how both regulators act co-ordinately we characterized two ncRNAs, RsmY and RsmZ, that link the LetA/LetS and CsrA regulatory networks," scientists writing in the journal Molecular Microbiology report. "We demonstrate that LetA directly regulates their expression and show that RsmY and RsmZ are functional in Escherichia coli and are able to bind CsrA in vitro. Single mutants have no (Delta rsmY) or a little...
Source: TB & Outbreaks Week (2009-06-23)
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