Legionnaire Disease

Reports outline legionnaire disease study findings from Boston University, Medical Department

Published in TB and Outbreaks Week, June 23rd, 2009

According to recent research from the United States, "During infection, Legionella pneumophila creates a replication vacuole within eukaryotic cells and this requires a Type IVb secretion system (T4bSS). IcmQ plays a critical role in the translocase and associates with IcmR."

"In this paper, we show that the N-terminal domain of IcmQ (Qn) mediates self-dimerization, whereas the C-terminal domain with a basic linker promotes membrane association. In addition, the binding of IcmR to IcmQ prevents self-dimerization and also blocks membrane permeabilization. However, IcmR does not completely block membrane binding by IcmQ. We then determined crystal structures of Qn with...

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Source: TB and Outbreaks Week (2009-06-23)

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