TB & Outbreaks Week
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Life Sciences
New life sciences research from P. Barthe and colleagues discussed
June 23rd, 2009
According to a study from Montpellier, France, "The Odhl protein is key regulator of the TCA cycle in Corynebacterium glutamicum. This highly conserved protein is found in GC rich Gram-positive bacteria (e.g., the pathogenic Mycobacterium tuberculosis)." "The unphosphorylated form of Odhl inhibits the OdhA protein, a key enzyme of the TCA cycle, whereas the phosphorylated form is inactive. Odhl is predicted to be mainly a single FHA domain, a module that mediates protein-protein interaction through binding of phosphothreonine peptides, with a disordered N-terminal extension substrate of the serine/threonine protein kinases. In this study, we solved the solution...
Source: TB & Outbreaks Week (2009-06-23)
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