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Tuberculosis
Research conducted at University of Florence has provided new information about tuberculosis
June 23rd, 2009
According to recent research from Florence, Italy, "The beta-carbonic anhydrase (CA, EC 4.2. 1.1) encoded by the gene Rv 1284 (mtCA 1) of Mycobacterium tuberculosis shows appreciable catalytic activity for CO, hydration, with a k(cat) of 3.9 x 10(5) s(-1) and a k(cat)/K-m of 3.7 x 10(7) M-1 s(-1). A panel of 36 sulfonamides and one sulfamate, some of which are used clinically, were assayed for their effect on mtCA 1 catalytic activity." "Most sulfonamides exhibited K-1 values in the range of 1-10 mc M, but several derivatives, including sulfanilyl-sulfonamides acetazolamide, methazolamide, dichlorophenamide, dorzolamide, brinzolamide, benzolamide, and the sulfamate...
Source: TB & Outbreaks Week (2009-06-23)
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