TB & Outbreaks Week
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Aspergillosis
Report summarizes aspergillosis study findings from State University of New York
June 23rd, 2009
According to recent research from the United States, "Chronic granulomatous disease (CGD) is an inherited disorder of the NADPH oxidase complex in which phagocytes are defective in generating superoxide anion and its metabolites. NADPH oxidase activation leads to activation of sequestered neutrophil proteases that mediate host defense." "Invasive aspergillosis and other rarer mold diseases are the leading causes of mortality in CGD, reflecting the key role of the phagocyte NADPH oxidase in host defense against opportunistic fungi. Despite recombinant interferon- prophylaxis, invasive filamentous fungal infections are a persistent problem in CGD. Key principles of...
Source: TB & Outbreaks Week (2009-06-23)
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