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Tuberculosis
New tuberculosis findings from S. Srivastava and co-researchers published
June 30th, 2009
According to recent research published in the International Journal of Medical Microbiology, "The emb locus has been considered a target for ethambutol (EMB). Substitutions of codon 306 in Mycobacterium tuberculosis embB have been shown to be the most frequent and predictive mutations for EMB resistance; however, recent reports question the biological role of this mutation." "We sequenced embB, embC and embR of 44 EMB-resistant M. tuberculosis strains and found that 30/44 (68.1%) strains had a resistance-associated mutation in one of the three genes sequenced. The majority of these mutations resulted in amino acid replacements at codon 306, 368, 378, and 406 of...
Source: TB & Outbreaks Week (2009-06-30)
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