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Tuberculosis
Reports summarize tuberculosis study results from V. Mathys and co-researchers
June 30th, 2009
According to a study from Singapore, Singapore, "The emergence of Mycobacterium tuberculosis resistant to first-line antibiotics has renewed interest in second-line antitubercular agents. Here, we aimed to extend our understanding of the mechanisms underlying para-aminosalicylic acid (PAS) resistance by analysis of six genes of the folate metabolic pathway and biosynthesis of thymine nucleotides (thyA, dfrA, folC, folP1, folP2, and thyX) and three N-acetyltransferase genes [nhoA, aac(1), and aac(2)] among PAS-resistant clinical isolates and spontaneous mutants." "Mutations in thyA were identified in only 37% of the clinical isolates and spontaneous mutants. Overall, 24...
Source: TB & Outbreaks Week (2009-06-30)
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