TB & Outbreaks Week
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Tuberculosis
Research from P. Kumar and co-authors provides new data about tuberculosis
June 30th, 2009
"Mycobacterium tuberculosis encodes for 11 eukaryotic-like serine/threonine protein kinases. Genetic and biochemical studies show that these kinases regulate various cellular processes including cell shape and morphology, glucose and glutamine transport, phagosome-lysosome fusion and the expression, and/or activity of transcription factors," scientists writing in the Journal of Biological Chemistry report. "PknK is the largest predicted serine/threonine protein kinase in M. tuberculosis. Here, we have cloned, overexpressed, and purified protein kinaseK(PknK) to near homogeneity and show that its ability to phosphorylate proteins is dependent on the invariant...
Source: TB & Outbreaks Week (2009-06-30)
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