TB & Outbreaks Week
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Dengue Fever
Research conducted at Q.Y. Wang and co-authors has provided new information about dengue fever
June 30th, 2009
According to recent research published in the journal Antimicrobial Agents and Chemotherapy, "The incidence of dengue fever epidemics has increased dramatically over the last few decades. However, no vaccine or antiviral therapies are available." "Therefore, the need for safe and effective antiviral drugs has become imperative. The entry of dengue virus into a host cell is mediated by its major envelope (E) protein. The crystal structure of the E protein reveals a hydrophobic pocket that is presumably important for low-pH-mediated membrane fusion. High-throughput docking with this hydrophobic pocket was performed, and hits were evaluated in cell-based assays....
Source: TB & Outbreaks Week (2009-06-30)
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