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Tuberculosis
Research in the area of tuberculosis reported from P. Belin and colleagues
July 7th, 2009
According to recent research from France, "The gene encoding the cytochrome P450 CYP121 is essential for Mycobacterium tuberculosis. However, the CYP121 catalytic activity remains unknown." "Here, we show that the cyclodipeptide cyclo(I-Tyr-I-Tyr) (cYY) binds to CYP121, and is efficiently converted into a single major product in a CYP121 activity assay containing spinach ferredoxin and ferredoxin reductase. NMR spectroscopy analysis of the reaction product shows that CYP121 catalyzes the formation of an intramolecular C-C bond between 2 tyrosyl carbon atoms of cYY resulting in a novel chemical entity. The X-ray structure of cYY-bound CYP121, solved at high resolution...
Source: TB & Outbreaks Week (2009-07-07)
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