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Tuberculosis
Studies from Y.J. Jung et al in the area of tuberculosis described
July 7th, 2009
"C57BL/6 (B6) and BALB/c mice are considerably more resistant to infection with Mycobacterium tuberculosis than DBA/2 mice. To determine whether the difference in resistance is because DBA/2 mice generate a type 1 T helper (Th1) immune response of lower magnitude, the Th1 response to airborne infection of mice of all 3 strains was measured in terms of the number of interferon (IFN)-gamma-producing CD4 and CD8 T cells generated," investigators in the United States report. "Despite the superior resistance of BALB/c mice compared with DBA/2 mice, both strains generated a similarly low number of Th1 cells. On the other hand, B6 mice, despite being approximately equal in...
Source: TB & Outbreaks Week (2009-07-07)
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