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Tuberculosis
Studies in the area of tuberculosis reported from State University of New York
July 7th, 2009
According to recent research from the United States, "Mycobacterium tuberculosis can metabolize cholesterol to both acetate and propionate." "The mass of isolated phthiocerol dimycoserate, a methyl-branched fatty acylated polyketide, was used as a reporter for intracellular propionate metabolic flux. When M. tuberculosis is grown using cholesterol as the only source of carbon, a 42 amu increase in average phthiocerol dimycoserate molecular weight is observed, consistent with the cellular pool of propionate and, thus, methylmalonyl CoA increasing upon cholesterol metabolism. In contrast, no shift in phthiocerol dimycoserate molecular weight is observed upon...
Source: TB & Outbreaks Week (2009-07-07)
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