Published in TB and Outbreaks Week, September 1st, 2009
"The K-i of 9 vs Mycobacterium tuberculosis lumazine synthase was 95 mc M. Compound 9 is a structural analogue of the lumazine synthase substrate 5-amino-6-(D-ribitylamino)-2,4-(1H,3H)pyrimidinedione (1). This indicates that the ribitylamino side chain of the substrate is not essential for binding to the enzyme," wrote A. Talukdar and colleagues, Purdue University.
The researchers concluded:...
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